Molecular and Medical Pharmacology
200. Introduction to Laboratory Research. (8) Laboratory, eight to 20 hours. Individual projects in laboratory research for beginning graduate students. At end of each term students submit to their supervisor reports covering research performed. Pharmacology graduate students must take this course three times during their first two years in residence. Letter grading.
203. Medical Pharmacology. (2) Lecture, zero to two hours; discussion, zero to two hours. Requisites: courses 211A, 211B. Series of lectures and case presentations designed to illustrate principles of pharmacology in a clinical context, and solution of practical therapeutics by reference to pharmacokinetics, mechanisms of action, and disposition of drugs. S/U or letter grading.
M205A. Introduction to Chemistry of Biology. (4) (Same as Chemistry CM205A.) Lecture, three hours; discussion, one hour. Introduction to chemical biology. Topics include computational chemical biology, utility of synthesis in biochemical research, peptidomimetics, designed reagents for cellular imaging, natural product biosynthesis, protein engineering and directed evolution, cell biology of metal ions, imaging metal ions in cells, metal-containing drugs. Letter grading.
M205B. Issues on Chemistry/Biology Interface. (2) (Same as Chemistry M205B.) Seminar, one hour. Requisite: course M205A. Selected talks and papers presented by training faculty on solving problems and utilizing tools in chemistry and molecular biology on chemistry/biology interface (CBI). S/U grading.
211A-211B. Principles of Pharmacology. (4-2) Lecture, three to eight hours; discussion, zero to nine hours. Preparation: mammalian physiology, biochemistry. Systematic consideration of principles governing interaction between drugs and biological systems and of principal groups of drugs used in therapeutics. Particular attention on modes of action, pharmacokinetics, and disposition to provide a scientific basis for their rational use in medicine. S/U or letter grading.
212A-212B. Graduate Commentary: Medical Pharmacology. (2-2) Preparation: mammalian physiology, biochemistry. Supplementation of topics covered in course 203. Primarily for graduate students. S/U or letter grading.
234A-234B. Experimental Methods in Pharmacology. (2-2) Laboratory, three hours. Survey of experimental methods and instrumentation used in analysis, identification, and study of mechanisms of action of pharmacologically active compounds. S/U or letter grading.
237. Research Frontiers in Cellular and Molecular Pharmacology. (6) Lecture, six hours; laboratory, five hours total. Detailed examination of principles of pharmacology and mechanisms of drug action at organismal, tissue, cellular, and molecular levels, with emphasis on receptors, receptor/effector coupling, neurotransmitters, cardiovascular pharmacology, autonomic and central nervous system pharmacology. Letter grading.
M241. Introduction to Chemical Pharmacology and Toxicology. (6) (Same as Molecular Toxicology M241.) Lecture, six hours. Preparation: organic and biological chemistry. Designed for molecular and medical pharmacology students. Introduction to general principles of pharmacology. Role of chemical properties of drugs in their distribution, metabolism, excretion, and modes of action. S/U or letter grading.
M248. Introduction to Biological Imaging. (4) (Same as Bioengineering M248 and Physics and Biology in Medicine M248.) Lecture, three hours; laboratory, one hour; outside study, seven hours. Exploration of role of biological imaging in modern biology and medicine, including imaging physics, instrumentation, image processing, and applications of imaging for range of modalities. Practical experience provided through series of imaging laboratories. Letter grading.
251. Seminar: Pharmacology. (2) Seminar, two hours. Required of all first- and second-year students. Presentation and discussion of graduate student research progress. Letter grading.
M257. Introduction to Toxicology. (4) (Same as Pathology M257.) Requisite: course M241. Biochemical and systemic toxicology, basic mechanisms of toxicology, and interaction of toxic agents with specific organ systems. S/U or letter grading.
M258. Pathologic Changes in Toxicology. (4) (Same as Pathology M258.) Designed to give students experience in learning normal histology of tissues which are major targets of toxin and the range of pathologic changes that occur in these tissues (liver, bladder, lung, kidney, nervous system, and vascular system). S/U or letter grading.
261. Institute for Molecular Medicine Seminar Series: Analysis and Discussion. (2) Seminar, one hour. Corequisite: course 251. Limited to graduate students. In-depth evaluation of Institute for Molecular Medicine (IMED) Seminar speakers, with focus on scientific approach and rationale, experimental methods, novel and pioneering findings (past and present), relevant background information on speakers and their institute, and presentation style and communication strengths. Discussion on characteristics that define and shape leaders in given fields. Students host lunches with seminar speakers, lead discussions to deconstruct all aspects of seminar presentations, and submit write-ups for online Wiki-postings on seminar-specific scientific topics. S/U grading.
286. Business of Science: Exploring Entrepreneurship Seminar. (1) Seminar, one hour. Limited to graduate students. Further exploration of topics discussed in course 287, allowing students to interact with speakers and bring their individual concerns to table. Past and present students encouraged to enroll. S/U grading.
287. Business of Science. (2) Lecture, two hours. Designed for graduate students. (undergraduate students may enroll with consent of instructor). Introduction to principles of business and entrepreneurship in technology sectors. Basic business skills taught to effectively perform in commercial environment and within academic environment. Application of course material by performing feasibility studies that have potential to receive funding and become actual companies. Exploration of entrepreneurship, particularly formation and operation of new business ventures. Presentations by and questioning of successful technology entrepreneurs, identifying and evaluating new venture opportunities, development of financing, and entry and exit strategies. S/U or letter grading.
288. Gene Therapy. (4) Lecture, three hours; discussion, one hour. Introduction to basic concepts of gene therapy, wherein treatment of human disease is based on transfer of genetic material into an individual. Discussion of molecular basis of disease, gene delivery vectors, and animal models. Letter grading.
291. Special Topics in Pharmacology. (4) Lecture, four hours. Examination in depth of topics of current importance in pharmacology. Emphasis on recent contributions of special interest to advanced PhD candidates and faculty. Letter grading.
292. Research Projects, Proposals, and Presentations. (6) Lecture, four hours; discussion, four hours. Limited to departmental majors. Introduction to format and requirements of research proposals, so students can critically read primary papers and give formal scientific presentations, ask new questions, formulate new hypotheses, and construct research projects, understand balance of importance, novelty, and feasibility, and develop ability to think independently, creatively, and comprehensively. Letter grading.
293. Nitric Oxide Chemistry, Biochemistry, and Physiology. (2 or 4) Lecture, two or four hours. Basic chemistry, biochemistry, and physiology of nitric oxide and related species, with emphasis on understanding novel mechanisms of nitrogen oxide function as both a physiological and pathophysiological agent/messenger. S/U or letter grading.
298. Seminar: Current Topics in Molecular and Medical Pharmacology. (2) Limited to pharmacology, ACCESS program, and interdepartmental Molecular Biology PhD program students. Students conduct or participate in discussions on assigned topics. S/U or letter grading.
375. Teaching Apprentice Practicum. (1 to 4) Seminar, to be arranged. Preparation: apprentice personnel employment as teaching assistant, associate, or fellow. Teaching apprenticeship under active guidance and supervision of regular faculty member responsible for curriculum and instruction at UCLA. May be repeated for credit. S/U grading.
596. Directed Individual Research in Pharmacology. (4 to 12) Tutorial, to be arranged. S/U or letter grading.
599. Research for and Preparation of PhD Dissertation. (4 to 12) Tutorial, to be arranged. S/U grading.