- Michael V. Drake, University President
- Nathan Brostrom, Executive Vice President; Chief Financial Officer
- Rachael Nava, Executive Vice President; Chief Operating Officer
- Katherine S. Newman, Executive Vice President, Academic Affairs; Provost
David Rubin, Executive Vice President; UC Health
Alexander Bustamante, Senior Vice President; Chief Compliance and Audit Officer - Michael Reese, Senior Vice President, External Relations and Communication (Interim)
- Charles F. Robinson, Senior Vice President; General Counsel
- Jagdeep Singh Bachher, Vice President, Investments; Chief Investment Officer
- Pamela Brown, Vice President, Institutional Research and Academic Planning
- Yvette Gullatt, Vice President, Graduate, Undergraduate, and Equity Affairs; Vice Provost; Chief Diversity Officer
- Glenda Humiston, Vice President, Agriculture and Natural Resources
- Cheryl Lloyd, Vice President, Human Resources
- Theresa A. Maldonado, Vice President, Research and Innovation
- Van Williams, Vice President, Information Technology Services; Chief Information Officer
- June Yu, Vice President, National Laboratories (Interim)
- Kathleen Fullerton, Associate Vice President, State Government Relations
- Christopher Harrington, Associate Vice President, Federal Government Relations