Engineering of Bioconjugates

BIOENGR C205 - Engineering of Bioconjugates

<p>Lecture, four hours; discussion, one hour; outside study, seven hours. Enforced requisites: Chemistry 20A, 20B, 20L. Highly recommended: one organic chemistry course. Bioconjugate chemistry is science of coupling biomolecules for wide range of applications. Oligonucleotides may be coupled to one surface in gene chip, or one protein may be coupled to one polymer to enhance its stability in serum. Wide variety of bioconjugates are used in delivery of pharmaceuticals, in sensors, in medical diagnostics, and in tissue engineering. Basic concepts of chemical ligation, including choice and design of conjugate linkers depending on type of biomolecule and desired application, such as degradable versus nondegradable linkers. Presentation and discussion of design and synthesis of synthetic bioconjugates for some sample applications. Concurrently scheduled with course C205. Letter grading.</p>

Bioengineering

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Henry Samueli School of Engineering and Applied Science

The department has created state-of-the-art facilities for cutting-edge research and developed an innovative curriculum for the education of the next generation of bioengineers.

General Catalog

Engineering of Bioconjugates

BIOENGR C105

4 units