<p>Lecture, four hours; discussion, one hour. Requisites: course 156, Mathematics 3C or 33A, Physics 1C or 5B. Methods for structure determination of biomacromolecules—proteins and nucleic acids—focusing on X-ray crystallography, cryo-EM imaging, and electron diffraction. Covers mathematical and computational methods used to obtain atomic structural models of biomolecules. Key physical principles include scattering phenomena, interference and diffraction, symmetry, Fourier transforms, and atomic interpretation of molecular structures in three-dimensions. Letter grading.</p>

Chemistry and Biochemistry

Combining rigorous, inclusive pedagogy with opportunities for co-curricular activities—including research, internships, and community engagement—the College provides students with diverse learning experiences that helps them thrive, become critical thinkers, and transform society.

College of Letters and Science

Chemistry is concerned with the composition, structure, and properties of substances, the transformations of these substances into others by reactions, and the kinds of energy changes that accompany these reactions.

General Catalog

Methods of Structural Molecular Biology: X-Ray Crystallography and Electron Microscopy

CHEM 230A

4 units