Lecture, three hours; discussion, one hour. Requisites: Life Sciences 3, 4, and 23L, or 7A, 7B, 7C, 23L, and 107. Development of understanding of fundamental molecular mechanisms and cellular activities guiding formation of complex organism from single fertilized egg. Development of model organisms to understand conserved nature of developmental decisions across animal kingdom, distinct features that lead to diversification of animal shape and form during evolution. Origin and roles of stem and progenitor cells in development and maintenance of specific organ systems. Roles of cell shape change, cell death, proliferation, and migration in generating shape of embryo, organs, and tissues. Mechanisms by which cells become different from and communicate with one another to coordinate their activities in time and space in embryo. Special emphasis on experimental approaches used to address these fundamental questions that determine how organized tissues and organs are formed and maintained throughout life of organism. Letter grading.
