<p>Lecture, three hours. Preparation: two biology courses. Requisites: course 100 and Biostatistics 100A, or Public Health 200A and 200B. Overview of virologic and immunologic aspects of HIV disease for epidemiology or other health disciplines. Brief discussion of clinical manifestations and biosafety in laboratory. Letter grading.</p>

Epidemiology

Jonathan and Karin Fielding School of Public Health

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EPIDEM 228 - Biology of HIV and SARS-CoV-2

Biology of HIV and SARS-CoV-2

Discuss the factors that make HIV difficult to both vaccinate against and cure, and summarize the HIV vaccine and cure efforts that are currently under investigation. 

Identify the origins of HIV and explain how HIV originally entered human populations. 

List the major components of the innate and adaptive immune response, and explain their function.

Describe the different classes of antiretroviral drugs, their mechanisms of action, and how they are evaluated in clinical trials. 

Explain the unique characteristics of HIV infection of women and the social/biological factors that contribute to infection in women.

Describe the HIV replication cycle and the function of the individual HIV proteins. 

Identify the most important features of the immune response against HIV and describe how HIV evades these host defenses.

Explain how HIV causes disease and list the most common clinical manifestations of HIV infection.

List and compare the most common animal models for studying HIV-infection.

Describe the scope of the worldwide HIV/AIDS pandemic and identify the countries and populations that are most affected.

General Catalog

Biology of HIV and SARS-CoV-2

EPIDEM 228

4 units